1560, Rouen. While the religious war between Catholics and Protestants rages on, Johannes Balsamo, an alchemist doctor, continues to initiate Martin into the art of elixirs. For the young apprentice, things seemed simple and his path was clear. But his destiny is about to shake him up. Soon forced to flee persecution, Martin goes into exile. Forced to protect his knowledge and to slip through the cracks of an evil prowling all over Europe, what paths will Martin have to take to accomplish the Great Work and obtain the Philosopher’s Stone, the Mother of all medicines?